Monitor Intently (2)pentobarbital will lower the extent or effect of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Potent CYP3A4 inducers could lessen suvorexant efficacy; if increased suvorexant dose necessary, never exceed 20 mg/daypentobarbital will minimize the extent or impact of theophylline by affect